Even if not existential---any one can lead to unprecedented human suffering that outweighs.
David Manheim 20, Research Fellow at the Foresight Institute, specializing in Global Catastrophic Risk Policy, “The Fragile World Hypothesis: Complexity, Fragility, and Systemic Existential Risk,” Futures, vol. 122, 09/01/2020, p. 102570
Bostrom recently suggested another possibility, the “Vulnerable World Hypothesis,” Bostrom (2019) where a technological advance occurs that will by default lead to extinction. He suggests that this is concerning, but notes that it is unclear if there are in fact such technologies in humanity's future. It is far more clear, however, that there are already technologies or events which would lead to global catastrophic risks short of extinction, and it seems implausible that more will not be found. Such events would create widespread devastation, could at least severely limit humanity's potential future advancement, and would at the very least cause tremendous human suffering and death in the short term. Bostrom, 2003; Bostrom (2003), Parfit (1984)