2. SMALL BUSINESSES – Alice/Mayo uniquely hurts them.
Hans Sauer 21, Deputy General Counsel, and Vice President for Intellectual Property for the Biotechnology Industry Organization and adjunct professor at Georgetown Law, 10/14/2021, "Comments submitted by Biotechnology Innovation Organization (BIO)," https://www.regulations.gov/comment/PTO-P-2021-0032-0128
More generally, it is also important to bear in mind that the impact of the current state of patent eligibility is disparate not only by technology, but also by categories of patentees. Thus, while manufacturing businesses and academic institutions, for example, are all to some degree affected, it has been shown that the “bite” of Section 101 jurisprudence is felt most acutely by independent inventors and small inventor-started businesses.11 In an economy that values individual entrepreneurship and startup company formation, the long-term effects of this phenomenon, if allowed to continue, need to be better-understood.