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In the context of IP Law, significant refers to close to or all of the relevant assets

Dyk 09 [Timothy Belcher Dyk, United States circuit judge of the United States Court of Appeals for the Federal Circuit, “In re SPIRITS INTERNATIONAL, N.V.”, No. 2008-1369, United States Court of Appeals, Federal Circuit, April 29, 2009, //zrubin]

Though varying linguistic formulations have been used, the wide consensus of the courts of appeals is consistent with the conclusion of the Third Circuit in Johnson & Johnson-Merck that the mark or advertising must deceive a substantial portion of the relevant consumers. See, e.g., Herman Miller, Inc. v. Palazzetti Imps. & Exps., Inc., 270 F.3d 298, 323 (6th Cir. 2001) ("tends to deceive a substantial portion of the intended audience"); Clorox Co. P.R. v. Proctor & Gamble Commercial Co., 228 F.3d 24, 33 n. 6 (1st Cir.2000) ("tendency to deceive a substantial segment of its audience"); United Indus. Corp. v. Clorox Co., 140 F.3d 1175, 1180 (8th Cir.1998); William H. Morris Co. v. Group W, Inc., 66 F.3d 255, 258 (9th Cir.1995) (stating that less than 3% is "[s]uch a small percentage" that it "does not constitute proof that a significant portion of recipients were deceived"); Johnson & Johnson * Merck Consumer Pharms. Co. v. Smithkline Beecham Corp., 960 F.2d 294, 297-98 (2d Cir.1992) ("a statistically significant part of the commercial audience").[4] See generally Richard J. Leighton, Materiality and Puffing in Lanham Act False Advertising Cases: The Proofs, Presumptions, and Pretexts, 94 Trademark Rep. 585 (2004). Under the circumstances it is clear that section (e)(3) — like subsection (a), the false advertising provision of the Lanham Act, and the common law — requires that a significant portion of the relevant consuming public be deceived. That population is often the entire U.S. population interested in purchasing the product or service.

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